01063nas a2200253   4500000000100000008004100001653001000042653003900052653002000091653001300111653001700124100001800141700001200159700001600171700001300187700001700200700001600217700001600233245010900249300001200358490000700370520041800377022001400795       2017                            d10aToxin10aNeglected tropical diseases (NTDs)10aMycolactone A/B10aExotoxin10aBuruli ulcer1 aSaint-Auret S1 aChany A1 aCasarotto V1 aTresse C1 aParmentier L1 aAbdelkafi H1 aBlanchard N00aTotal syntheses of mycolactone A/B and its analogues for the exploration of the biology of Buruli ulcer.  a836-8400 v713 a<p>Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.</p>
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