01708nas a2200193   4500000000100000008004100001653001200042653002400054653002200078653001400100653001900114100001300133700001300146245008400159856007300243300001200316490000700328520117900335       2017                            d10aleprosy10aTuberculoid leprosy10aS-100 immunostain10aGranuloma10aNerve elements1 aSharma A1 aSharma R00aS-100 immmunostain as an ancillary aid in the diagnosis of tuberculoid leprosy.  uhttp://www.jkscience.org/archives/volume192/9-Original%20Article.pdf  a103-1060 v193 a<p>To study the patterns of nerve involvement in tuberculoid leprosy using S-100 immunostain and to compare its sensitivity with that of hematoxylin and eosin stain. The paraffin sections of twenty five cases of leprosy including five of tuberculoid (TT) and 20 of borderline tuberculoid (BT) type were subjected to both H&amp; E and S-100 immunostaining. The patterns of nerve involvement on S-100 immunostaining were graded as infiltrated (A), fragmented (B), absent (C) and intact (D). On H&amp;E staining only 2/5 (40%) TT cases and 9/20 (45%) of BT cases revealed neural inflammation. On S-100 staining of TT cases, 3/5 (60%) showed pattern B of nerve involvement followed by pattern A and C in 1/5 (20%) and 1/5 (20%) cases respectively. Out of the 20 cases of BT, S-100 demonstrated B pattern of nerve involvement in 14 (70%), A in 5 (25%) and C in 1 (5%). S-100 Stain is an efficient ancillary aid in histopathological diagnosis of tuberculoid pole of leprosy and is superior to H&amp;E stain in identifying the neural inflammation in granulomas. The fragmented pattern of nerve involvement was the most common pattern seen in both TT (60%) and BT (70%) cases.</p>