01791nas a2200385   4500000000100000008004100001653001600042653001700058653001900075653001600094653001200110653001100122653001300133653000900146653001000155653001500165100001600180700001300196700001500209700001600224700001200240700002400252700001300276700002200289700001300311700001200324700001600336700001200352245008800364856005100452300001100503490000700514520087000521022001401391       2016                            d10aYoung Adult10aTuberculosis10aPilot Projects10aMiddle Aged10aleprosy10aHumans10aArkansas10aAged10aAdult10aAdolescent1 aCardenas VM1 aOrloff M1 aKaminaga J1 aCardenas IC1 aBrown J1 aHainline-Williams S1 aDuthie M1 aGonzalez-Puche AC1 aMukasa L1 aPatil N1 aMcelfish PA1 aBates J00aTuberculosis and leprosy infections in the Marshallese population of Arkansas, USA.  uhttps://leprosyreview.org/article/87/1/10-9112  a109-120 v873 a<p>The cross-immunity between tuberculosis and leprosy is unknown. The aim of this pilot study was to evaluate the occurrence of Mycobacterium tuberculosis and M. leprae infection in Marshallese adult volunteers in Springdale, Arkansas, U.S.A., a population that experiences high rates of leprosy and tuberculosis. We used immunodiagnostic testing for tuberculosis and leprosy infection and found significant prevalence of latent tuberculosis infection (19.0%), and asymptomatic Mycobacterium leprae infection (22.2%). We found a negative association between presence of antibodies to Mycobacterium leprae and a positive interferon-γ release assay for Mycobacterium tuberculosis infection, prevalence odds ratio = 0.1 (95% CI = 0.0, 0.9). Although these findings require confirmation on a larger scale, they are supportive of the existence of cross-immunity.</p>
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