01035nas a2200181   4500000000100000008004100001653001600042653001200058653001000070653001200080653003200092653001300124100001300137245002200150300001000172490000700182520066400189       2006                            d10aClofazimine10aDapsone10aDrugs10aleprosy10aMultiple-drug therapy (MDT)10aRifampin1 aPark E M00aDrugs in leprosy.  a49-580 v393 a<p>Chemotherapy is a main component of treatments for leprosy. The World Health Organization (WHO) recommends multiple-drug therapy (MDT) consisting of dapsone, clofazimine and monthly rifampin as the first-line drugs against leprosy. Minocycline, clarithromycin and certain fluoroquinolones can be used as substitutes in dapsone or clofazimine. For management of reactions, type I reactions should be treated with corticosteroids while thalidomide is the drug of choice for type II reaction. This review summarizes pharmacologic effects of drugs being used in leprosy including mechanisms of action, side effects, drug interactions and drug resistance.</p>