00967nas a2200169 4500000000100000008004100001653002000042653001200062653001400074100001200088700001300100700001200113245006400125300001000189490000700199520059100206 2006 d10aInfection model10aleprosy10aZebrafish1 aKim J P1 aChoi H Y1 aCho S N00aPossibility of Zebrafish as New infection model for Leprosy a37-480 v393 a

The zebrafish emerged as a new model of developmental research and infection. Recently zebrafish were used for various mycobacterial infection studies. In this study, we investigated a possibility of the zebrafish as an infection model of Mycobacterium leprae infection. We injected Mycobacterium leprae (10(5)/30microliter) to the peritoneum of zebrafish. After 4 weeks, we found two fish evident to the subsistence and multiplication of Mycobacterium leprae, among total 25 fish. This study thus demonstrates that zebrafish may become an animal model for M. leprae infection.