01381nas a2200181   4500000000100000008004100001100001400042700001600056700001400072700002100086700001200107700001200119700001300131700001600144245012100160520090400281022001401185       2018                            d1 aMacedo CS1 aCarvalho FM1 aAmaral JJ1 aMendonça Ochs S1 aAssis E1 aSarno E1 aBozza PT1 aPessolani M00aLeprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators.3 a<p>The disease leprosy is caused by Mycobacterium leprae. The disease displays a spectrum of clinical manifestations relating to the stage of the infection and the pathogen-specific immune response. The most frequent M. leprae-specific hypersensitivity reactions are erythema nodosum leprosum (ENL) and type-1 (reversal) reaction (T1R). Omega-3 and omega-6 fatty acid-derived lipid mediators are involved in the regulation of these M. leprae-specific inflammatory and immune responses. Studies on lipid mediators showed their presence during different manifestations of leprosy-before and after multidrug therapy (MDT) and during T1R. This review aims to compare the lipid mediators at different stages of the disease. This review also presents new data on the significance of lipid mediators (cysteinyl leukotrienes and leukotriene B, prostaglandin E and D, lipoxin A and resolvin D1) on ENL.</p>
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