02108nas a2200265   4500000000100000008004100001653001200042653002100054653002500075653002900100653002600129100002400155700002600179700001600205700002700221700003000248700001900278700003300297700001900330700001400349245007300363300000800436520138400444022001401828       2018                            d10aleprosy10aHansen's disease10aMycobacterium leprae10aTherapeutic compositions10aTreatment for leprosy1 aGomes Lima Santos N1 aPerez Pereira Ramos K1 aShanmugam S1 aOliveira de Carvalho F1 aGarcez Barreto Teixeira L1 aRamos Silva É1 aVasconcelos Cerqueira-Braz J1 aSantos Nunes P1 aAraújo A00aNew therapeutic patents used for the treatment of leprosy: a review.  a1-43 a<p>Leprosy is a granulomatous disease, infectious and transmissible, which affects the skin and peripheral nerves, having Mycobacterium leprae as causative agent. The manifestation of this disease causes cutaneous lesions, peripheral neuropathies and, in more extreme cases, may generate deformities and disabilities in affected individuals. Patents were identified using the descriptor 'leprosy' and code A61K of the international patent classification, which indicates only products that meet human needs. The analysis was made using the WIPO, ESPACENET and USPTO databases, until the month of September 2016. Through this review, we found a variety of in vitro, pre-clinical and clinical studies relating to the treatment of leprosy with different types of compounds and forms of administration. New treatment proposals should include pain reduction capabilities, prevention or limitation of the appearance of cutaneous lesions, as well as prevention of the progression of the disease to more severe stages that may lead to loss of function or potentiate the individual's immune response to the M. leprae bacillus in order to prevent bacterial spread. We concluded that any patents developed with natural products were not found in the treatment of leprosy. All the deposited products were synthetic origin, mostly tested in humans and of varied forms of administration.</p>
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