02374nas a2200265   4500000000100000008004100001653001200042653001100054653003200065653003600097653001200133653001600145653002200161653001000183100001400193700001400207700001300221700001200234700001500246245020400261856003300465300001200498490000600510520159200516       2018                            d10aleprosy10aBurden10aHistomorphological spectrum10aClinicopathological correlation10aHansens10aH & E stain10aFite Faraco stain10aIndia1 aFirdous F1 aSridevi P1 aMajeed A1 aKirit R1 aAbeddin MA00aTo assess the burden of and trends of Hansens disease - Mainly by assessing the histomorphological spectrum and clinicopathological correlation, at a tertiary care hospital in Telangana State, India.  uhttps://tinyurl.com/yaamatce  a148-1540 v43 a<p><strong>Context: </strong>Leprosy an important public health problem which needs to be addressed. <strong>Aims: </strong>We study the histopathological features of leprosy in skin biopsies and categorize them into various types based on microscopic features. Clinico pathological correlation was done in all cases. <strong>Materials and Methods: </strong>Skin biopsies after adequate fixation in 10% of formalin, were routinely processed and paraffin embedded sections of 5 μ thickness were stained with H and E and fite -faraco stain and were studied microscopically. <strong>Results: </strong>A total of 1200 skin biopsies were obtained from patients of skin department during a period of two years from May 2016 to May 2018,out of which 136 cases were clinically diagnosed as Hansens and among them 116 were confirmed as Hansens histologically . Among them - Lepromatous leprosy 61 cases,- Borderline lepromatous leprosy 18 cases, Tuberculoid leprosy-11 cases, Borderline tuberculoid leprosy- 19 cases and lepra reaction[ENL]-7 cases, rest 20 cases included indeterminate leprosy and other d/ds. With an age range of 11 -68 years, majority were in 2nd decade, with male to female ratio of 2.5:1. LL was the most common type of leprosy (%). Majority of biopsies were of multibacillary type (52.5%). Clinicopathological correlation was observed in all cases. <strong>Conclusions: </strong>For diagnosis, correlation of clinical and histopathological features along with special stain [fite faraco] appears to be more useful than considering any of the single parameters alone.</p>