02510nas a2200277   4500000000100000008004100001653001100042653001700053653001200070653001400082653002100096100001300117700002000130700001600150700001800166700001700184700001400201700002000215700001900235245010600254856007000360300001200430490000700442520176900449022001402218       2018                            d10aBrazil10aEpidemiology10aleprosy10aMortality10aSpatial analysis1 aSouza EA1 aNzundu Boigny R1 aOliveira HX1 aOliveira MLWD1 aHeukelbach J1 aAlencar C1 aMartins-Melo FR1 aNovaes Ramos A00a[Spatiotemporal patterns of leprosy-related mortality in Bahia state, northeastern Brazil, 1999-2014]  uhttp://www.scielo.br/pdf/cadsc/v26n2/1414-462X-cadsc-26-2-191.pdf  a191-2020 v263 a<p><strong>Background</strong><br />
Leprosy is a neglected condition with a high mortality burden, especially in poorer areas. The objective of this study was to analyze temporal trends and spatiotemporal patterns of mortality related to leprosy in the state of Bahia, 1999-2014.</p>

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<p><strong>Objective</strong><br />
To analyze the spatiotemporal trends and patterns of mortality associated with leprosy in the state of Bahia, Brazil, from 1999 to 2014.</p>
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<p><strong>Method</strong><br />
Population-based study utilizing secondary mortality data including all deaths, in which leprosy was mentioned, recorded in the state of Bahia from 1999 to 2014.</p>
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<p><strong>Results</strong><br />
From a total of 1,152,262 deaths, leprosy was identified in 481 (0.04%) cases, resulting in a mean annual gross mortality rate of 0.21 deaths/100,000 inhabitants (95% confidence interval [CI]: 0.13-0.29). Unspecified leprosy (87.73%; 422/481) and leprosy complications (6.44%; 31/484) were the most commonly reported clinical forms. Risk of death associated with leprosy was higher among men (relative risk [RR]: 2.38; 95% CI; 0.19-0.46), elderly (RR: 74.79; 95% CI; 9.57-582.20), and in the eastern region of the state (RR: 4.08; 95% CI; 2.33-7.15). Overall mortality rates showed a significant increase during the observation period (Average Annual Percentage Change [AAPC] 7.3, 95% CI; 4.5-10.3), as well as proportional mortality (AAPC 5.3; 95% CI; 2.2-8.3).</p>
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<p><strong>Conclusions</strong><br />
Leprosy is a neglected cause of death in the state of Bahia. The disease presents unequal regional spatiotemporal trends, with risks associated mainly in males and older age groups.</p>
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