02585nas a2200349   4500000000100000008004100001653002500042653002500067653002900092653002500121653002000146100001300166700001300179700001300192700001400205700001500219700001700234700001600251700001500267700001000282700001600292700001400308700001700322700001100339700001100350245017000361856006400531300001400595490000600609520160600615022001402221       2018                            d10aMycobacterium uberis10aEvolutionary biology10aGranulomatous dermatitis10aVeterinary pathogens10aGenome analysis1 aBenjak A1 aAvanzi C1 aBenito Y1 aBreysse F1 aChartier C1 aBoschiroli M1 aFourichon C1 aMichelet L1 aPin D1 aFlandrois J1 aBruyere P1 aDumitrescu O1 aCole S1 aLina G00aHighly Reduced Genome of the New Species, the Causative Agent of Nodular Thelitis and Tuberculoid Scrotitis in Livestock and a Close Relative of the Leprosy Bacilli.  uhttps://msphere.asm.org/content/msph/3/5/e00405-18.full.pdf  ae00405-180 v33 a<p>Nodular thelitis is a chronic enzootic infection affecting dairy cows and goats. The causative agent was recently shown to be related to the leprosy-causing bacilli and In this study, the genome of this pathogen was sequenced and analyzed. Phylogenomic analyses confirmed that the pathogen present in nodular thelitis and tuberculoid scrotitis is a distinct species related to the leprosy bacilli and Because the pathogen was originally isolated from a bovine udder, it was named "" The genome of "" is only 3.12 Mb in length, which represents the smallest mycobacterial genome identified so far but which is close to that of leprosy bacilli in size. The genome contains 1,759 protein-coding genes and 1,081 pseudogenes, indicative of extensive reductive evolution and likely the reason that cannot be grown axenically. The pseudogenization and genome reduction in seem to have been to some extent independent from the results determined for the genomes of the leprosy bacilli. is an emerging skin pathogen in dairy animals. Its genome underwent massive reduction and gene decay, leading to a minimal set of genes required for an obligatory intracellular lifestyle, which highly resembles the evolution of the leprosy agents and The genomic similarity between and the leprosy bacilli can help in identifying key virulence factors of these closely related species or in identifying genes responsible for the distinct differences between thelitis or scrotitis and leprosy with respect to clinical manifestations. Specific DNA markers can now be developed for quick detection of this pathogen.</p>
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