01596nas a2200193   4500000000100000008004100001653001200042653000900054653001000063100001700073700001700090700001300107245007800120856009800198300001300296490000700309520107200316022001401388       2018                            d10aleprosy10aTLR110aWomen1 aNiitsuma ENA1 aFernandes GR1 aLana FCF00aThe TLR1 gene is associated with higher protection from leprosy in women.  uhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0205234&type=printable  ae02052340 v133 a<p>Leprosy is an infectious disease with a complex genetic and immunological background. Polymorphisms in genes that encode cytokines and receptors involved in the immune response, such as the Toll-like receptor 1 (TLR1), may be associated with disease risk. We hypothesized that polymorphisms in innate immunity genes confer susceptibility to leprosy that differs between women and men. In this study, we investigate sex differences in the association between a single nucleotide polymorphism (SNP) in TLR1 and Nucleotide-binding oligomerization domain containing 2 (NOD2) genes and leprosy susceptibility in 256 clinically classified leprosy patients and 233 control subjects in a Brazilian population. Our results showed no association between the SNP rs8057341 in NOD2 and leprosy in this population. However, the heterozygous genotype of the TLR1 SNP (rs4833095) showed a statistically significant association in women (OR = 0.54, P = 0.02). Our findings suggest that the TLR1 polymorphism was associated with an increased protection from leprosy in women.</p>
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