02181nas a2200289   4500000000100000008004100001653001200042653002000054653001500074653000800089653001900097653001900116653001200135653001000147100001300157700001200170700001800182700001300200700001100213700001300224245010100237856005200338300001200390490000600402520146900408022001401877       2018                            d10aleprosy10aDrug Resistance10aDisability10aMDT10aMultibacillary10aPaucibacillary10aRelapse10aIndia1 aGitte SV1 aNigam C1 aChakraborty A1 aKamble K1 aSoni M1 aGahlot R00aProfile of Person Affected by Leprosy with Clinical Relapse among in High Endemic State of India  uhttp://dergipark.gov.tr/doi/10.5799/jmid.458458  a103-1070 v83 a<p><strong>Objective: </strong>Relapse is not an unusual phenomenon in leprosy, there are many predisposing factors which may lead to occurrence of relapse; some of these include the presence of persistent bacilli, drug monotherapy, inadequate or irregular therapy. Patients usually presents with presence of multiple skin lesions and/or thickened nerves, reason for early relapse is probably bacillary persistence due to inadequate treatment and for late relapse due to or re-infection. The objectives of this study are to assess various clinico-epidemiological factors associated with the occurrence of relapses in leprosy patients.</p>

<p><strong>Methods: </strong>A hospital record based retrospective follow-up study has been performed and 117 relapse cases of leprosy were included. Leprosy relapse cases presented in the study hospital were interviewed using a predesigned and pretested preformed. Each patient was subjected to clinical, bacteriological and disability assessments for diagnosis of relapse and followed until the completion of multi drug therapy.</p>

<p><strong>Results: </strong>During a study period, relapse was seen more in male as compared to female. The duration between cessation of treatment and re-appearance of new lesions varied from 1 to 33 years. Disability proportion was high among MB patients.</p>

<p><strong>Conclusion: </strong>Relapse in leprosy should be thoroughly examined and looked for drug resistance.</p>
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