01456nas a2200229   4500000000100000008004100001653001200042653002600054653001900080653001800099653002400117100001400141700002800155700001300183700001400196700001800210700001200228700002000240245013500260520081700395022001401212       2018                            d10aleprosy10aGenetic polymorphisms10aInterleukin-1710aInterleukin-810aReactional episodes1 aAquino JS1 aAmbrosio-Albuquerque EP1 aAlves HV1 aMacedo LC1 aVisentainer L1 aSell AM1 aVisentainer JEL00aIL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil.3 a<p>We evaluated the influence of the IL8 T-738A (nonidentified rs), IL8 T-353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single-nucleotide polymorphisms on leprosy. The AA genotype of IL8 T-353A was observed as a risk factor for multibacillary leprosy, regardless of gender and age-of-onset of disease, considering the recessive model (OR, 3.8; 95% CI, 1.1-13.5; P, 0.023). Furthermore, the AA genotype of IL17A G197A was associated with leprosy type 1 reaction (OR, 2.4; 95% CI, 1.1-5.1; P, 0.026) when compared to the group without reaction, which was adjusted for gender and age-of-onset of disease by the model log additive. These results indicate association of IL8 and IL17A polymorphisms with the progression to multibacillary leprosy and with the type 1 reaction, respectively.</p>
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