01150nas a2200205   4500000000100000008004100001260001500042653001200057653002000069653002200089653002000111653003600131100001200167700001200179700001200191245002200203856004600225300000700271520066600278       2018                            d  bIntechOpen10aleprosy10aType 1 reaction10aReversal reaction10aType 2 reaction10aErythema nodosum leprosum (ENL)1 aBilik L1 aDemir B1 aCicek D00aLeprosy Reactions  uhttps://cdn.intechopen.com/pdfs/58135.pdf  a113 a<p>Sudden changes in immune-mediated response to Mycobacterium leprae antigen are referred to as leprosy reactions. The reactions manifest as acute inflammatory episodes rather than chronic infectious course. There are mainly two types of leprosy reactions. Type 1 reaction is associated with cellular immunity and particularly with the reaction ofThelper1(Th1)cellstomycobacterialantigens.Thisreactioninvolvesexacerbationof old lesions leading to the erythematous appearance. Type 2 reaction or erythema nodosum leprosum (ENL) is associated with humoral immunity. It is characterized by systemic symptoms along with new erythematous subcutaneous nodules.</p>