01439nas a2200217   4500000000100000008004100001653001200042653002400054653001900078653002200097653001300119653001800132100001200150700001300162700001000175245021700185856007800402300001200480490000700492520072200499       2018                            d10aleprosy10alepromatous leprosy10aDepigmentation10aMultidrug therapy10aVitiligo10aNeural theory1 aKumar P1 aSavant S1 aDas A00aA curious case of Lepromatous Leprosy Developing Complete loss of Pigmentation, followed by Reappearance of Pigmentation with Multi Drug Therapy (MDT) alone - A Support for Neural Theory of Vitiligo Pathogenesis?  uhttp://www.ijl.org.in/2018/8%20P%20Kumar%20et%20al%20(CR)%20(155-159).pdf  a155-1590 v903 a<p>Lepromatous leprosy is a multisystem disease characterized by a decline in delayed hypersensitivity to <em>Mycobacterium leprae </em>antigens, causing multiplication of bacilli in huge numbers. We herein report a case of an adult male with lepromatous leprosy who was started on adult multibacillary multi-drug therapy. With treatment, the surface of lesions developed depigmented macules and patches. However, on continuation of antileprotic drugs, there was progressive perifollicular as well as inter-follicular re-pigmentation. This case clinically depicts re-pigmentation of depigmented skin following multidrug therapy for leprosy supporting the role of neural system in the homeostasis of melanocytes.</p>