01476nas a2200181   4500000000100000008004100001653001200042653002200054653001500076100001400091700001600105700001100121700001900132700001400151245005900165856009800224520097200322       2017                            d10aleprosy10aReversal reaction10aMast Cells1 aYuniati R1 aFatihatul F1 aFika A1 aPrasetyowati S1 aIndropo A00aMast Cells in Leprosy Patients with Reversal Reactions  uhttp://eprints.undip.ac.id/75295/1/Mast_Cells_in_Leprosy_Patients_with_Reversal_Reactions.pdf3 a<p>Background: Reversal reaction (RR) is an acute reaction on chronic episode which often contributes to withdrawal of treatment and disability in leprosy patients. Previous study showed that mast cells in reactive tuberculoid lesions biopsy material had lower density than non reactive tuberculoid lesions. Granulomatous lesions in leprosy patients with high mast cells density were more likely to progress into severe reversal reaction. Objective: To examine mast cells level in reversal reaction patients (RR) and non-reactional leprosy patients (non-RR) Methods: Fiftysix leprosy patients consist of 28 with reversal reactions and 28 non-reactional leprosy were assessed for mast cells levels by immunohistochemistry staining. The mast cell numbers in both groups were analyzed using Independent T-test. Results: Mast cells were increased in the reversal group (p&lt;0.05). Conclusion: Mast cells level is associated with reversal reaction of leprosy.&nbsp;</p>