02483nas a2200445   4500000000100000008004100001260001300042653002400055653001800079653002500097653002400122653001100146653001900157653001100176653002800187653001300215653002300228653002000251653003700271653003100308653002000339653003800359653001400397653001400411653002200425653001400447653003200461653002600493653002600519653001800545100001500563700001100578700001300589700001400602700001300616245017500629300001100804490000600815520121600821       1976                            d  c1976 Oct10aAutoimmune Diseases10aB-Lymphocytes10aDeveloping countries10aDiarrhea, Infantile10aFemale10aFetal Diseases10aHumans10aImmune Complex Diseases10aImmunity10aImmunity, Cellular10aImmunoglobulins10aImmunologic Deficiency Syndromes10aInfant Nutrition Disorders10aInfant, Newborn10aInfant, Small for Gestational Age10aMorbidity10aNeoplasms10aPlacenta Diseases10aPregnancy10aProtein-Energy Malnutrition10aSocioeconomic Factors10aStress, Physiological10aT-Lymphocytes1 aRossipal E1 aDutz W1 aKohout E1 aGhavami H1 aVessal K00a[Considerations regarding the influence of intrauterine and early postnatal diseases and nutritional deficiencies on immunity and disease epidemiology (author's transl)].  a229-350 v43 a<p>Malnutrition, infectious and toxic stress, hormonal and enzymatic deficiencies as well as graft versus host reactions during the last trimester of pregnancy and during the first six months of life lead to persistent depressions of cell mediated immunity. The subsequent imbalance between the cell mediated and humoral system of immunity leads to differences in disease prevalence in poor and rich populations. Particularly leprosy, tuberculosis, viral disease as for instance frequently fatal measles and diseases due to complexes between humoral antibody and bacterial components as for example acute rheumatic fever occur with increased frequency in B (+) T (-) populations. Desturbances of immune surveillance due to suppression of specific cell mediated immune function leads to an increased frequency of neoplasia, particularly B-cell lymphoma and gastrointestinal tumors. Populations in which the T-cell system can mature without interference show a trend towards diseases in which excessive T-cell response plays a major role, as for instance rheumatoid arthritis, Sjögren syndrome, terminal ileitis, autoimmune angiopathies, multiple sclerosis and possibly also disseminated lupus erythematodes.</p>