01539nas a2200361   4500000000100000008004100001260000900042653001000051653001600061653001200077653002100089653002100110653001600131653001100147653002300158653002500181653000900206653002500215653001300240100001300253700001100266700001500277700001400292700001200306700001200318700001400330700001600344245005400360300001100414490000700425520073100432022001401163       2003                            d  c200310aAdult10aClofazimine10aDapsone10aErythema Nodosum10aFluoroquinolones10aHistiocytes10aHumans10aLeprostatic Agents10aLeprosy, lepromatous10aMale10aMycobacterium leprae10aRifampin1 aAlioua Z1 aSbai M1 aElhaouri M1 aBouzidi A1 aBoudi O1 aGhfir M1 aBenomar S1 aSedrati O L00a[Histoid leprosy with erythema nodosum leprosum].  a107-110 v123 a<p>Histoid leprosy is a particular variant of lepromatous leprosy presenting as cutaneous or subcutaneous nodular and/or plaque-like lesions arising form apparently normal skin. It is characterized histologically by spindle-shaped histiocytes in interlacing bundles and whorls, containing numerous intact and rod-shaped Mycobacterium leprae. It can occur de novo or secondary in patients treated for a long course by dapsone alone. We describe a case of lepromatous leprosy treated according to the national Moroccan protocol who developed histoid lesions during his treatment by dapsone. The patient responded well to fluoroquinolone, rifampicin and clofazimine, with however, the occurrence of erythema nodosum leprosum.</p>  a0001-5938