01528nas a2200325   4500000000100000008004100001260001300042653002000055653003100075653003800106653001800144653001100162653001300173653001200186653002500198653002500223653001300248653003000261100001400291700001200305700001500317700001300332700001100345245004700356300000900403490000700412050001600419520075300435022001401188       2005                            d  c2005 Feb10aChronic Disease10aGene Expression Regulation10aGenetic Predisposition to Disease10aGenome, Human10aHumans10aImmunity10aleprosy10aMolecular Chaperones10aMycobacterium leprae10aProteins10aUbiquitin-Protein Ligases1 aAlcaïs A1 aMira MT1 aCasanova J1 aSchurr E1 aAbel L00aGenetic dissection of immunity in leprosy.  a44-80 v17  aALCAIS 20053 a<p>Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects an estimated 700,000 new individuals each year. A strong contribution of host genetics to susceptibility to leprosy has long been suggested to account for the considerable variability observed between individuals exposed to M. leprae. As there is no relevant animal model for human leprosy, forward genetics is the main strategy used to identify the genes and, consequently, the immunological pathways involved in protective immunity to M. leprae. With respect to genome-wide screens, a major breakthrough has been reported this year; variants in the regulatory region shared by PARK2 and PACRG have been identified as being common risk factors for leprosy.</p>  a0952-7915