02649nas a2200457   4500000000100000008004100001260001300042653001500055653001000070653000900080653002200089653002600111653002400137653001000161653002100171653001300192653002800205653003800233653001100271653001600282653001100298653002100309653002200330653001300352653002500365653000900390653001600399653002500415653001700440100002100457700002500478700002100503700001500524245014400539856005500683300001000738490000800748050002200756520139900778022001402177       2005                            d  c2005 Nov10aAdolescent10aAdult10aAged10aAged, 80 and over10aAntibodies, Bacterial10aAntigens, Bacterial10aChild10aChild, Preschool10aColombia10aCross-Sectional Studies10aEnzyme-Linked Immunosorbent Assay10aFemale10aGlycolipids10aHumans10aImmunoglobulin G10aIntradermal Tests10aLepromin10aLeprosy, lepromatous10aMale10aMiddle Aged10aMycobacterium leprae10aRisk Factors1 aCardona-Castro N1 aRestrepo-Jaramillo S1 aGil de la Ossa M1 aBrennan PJ00aInfection by Mycobacterium leprae of household contacts of lepromatous leprosy patients from a post-elimination leprosy region of Colombia.  uhttp://www.scielo.br/pdf/mioc/v100n7/v100n7a03.pdf  a703-70 v100  aCARDONACASTRO20053 a<p>The Leprosy Control Program of Antioquia, (post-elimination leprosy state of Colombia), had registered by 1999, 56 lepromatous leprosy patients and their household contacts (HHC). Our interest was to detect Mycobacterium leprae infection in these HHC. Clinical examination, acid-fast bacillary staining (AFB) in nasal secretions, and slit skin samples, IgM anti-PGL-I in serum and Lepromine A (Mitsuda) reactivity were tested. Two hundred forty eight HHC were studied, 49% were male. After clinical examination, two HHC were diagnosed as multi bacillary patients; 13% showed positive IgM anti-PGL-I titers; Mitsuda reaction (> or = 4 mm) was positive in 59%; AFB was negative in all samples, except in the two new patients. HHC were classified according to test results. Group 1: two new multi bacillary patients. Group 2: 15 HHC seropositive, Mitsuda-negative. Group 3: 13 HHC seropositive, Mitsuda-positive. Group 4: 130 HHC seronegative, Mitsuda-positive. Group 5: 88 HHC seronegative, Mitsuda-negative. These results are an indication that the transmission of the infection is still happening in a region considered in the post elimination phase. The two new patients represent an infection source for others contacts, and groups 2 and 3 are infected HHC that could develop the disease in future. Follow up of high risk population is necessary to achieve real elimination of leprosy.</p>  a0074-0276