01971nas a2200337   4500000000100000008004100001260001300042653001500055653001000070653000900080653001200089653001000101653002800111653001100139653001100150653000900161653001600170653001800186653001700204100001600221700001400237700001700251700001500268700001400283700001200297245006900309300001100378490000700389520122300396022001401619       2007                            d  c2007 Feb10aAdolescent10aAdult10aAged10aBahrain10aChild10aDiagnosis, Differential10aFemale10aHumans10aMale10aMiddle Aged10aRhinoscleroma10aSaudi Arabia1 aAbalkhail A1 aSatti M B1 aUthman M A E1 aAl Hilli F1 aDarwish A1 aSatir A00aRhinoscleroma: a clinicopathological study from the Gulf region.  a148-510 v483 a<p><b>INTRODUCTION: </b>Rhinoscleroma is a chronic progressive inflammatory disease of the upper respiratory tract. We report a clinicopathological series from the Gulf region.</p><p><b>METHODS: </b>The clinical and pathological features of patients diagnosed with rhinoscleroma at three main hospitals in Saudi Arabia and Bahrain over a 20-year period are presented. Archived glass slides and paraffin blocks from these patients were retrieved from the pathology files for review. Special stains were performed whenever indicated. Biopsy material and clinical data from 25 patients formed the basis of this study.</p><p><b>RESULTS: </b>Most of the patients were young females with a median age of 24 years. The nose was involved in all cases with frequent extension to other parts of the upper respiratory tract. The provisional clinical diagnoses included syphilis, midline granuloma and malignancy. The histological differential diagnoses included leprosy, malakoplakia and metastatic renal cell carcinoma.</p><p><b>CONCLUSION: </b>Rhinoscleroma is rare in Saudi Arabia and Bahrain. Awareness of possible clinical presentations and early diagnosis will significantly reduce the morbidity caused by this disease.</p>  a0037-5675