01477nas a2200289   4500000000100000008004100001260001300042653001200055653001900067653003000086653001700116653001200133653000900145653001600154653002500170653001300195100000900208700001500217700001600232245013800248856007700386300001100463490000700474050001200481520068000493022001401173       1991                            d  c1991 Mar10aAnimals10aClarithromycin10aDrug Therapy, Combination10aErythromycin10aleprosy10aMice10aMinocycline10aMycobacterium leprae10aRifampin1 aJi B1 aPerani E G1 aGrosset J H00aEffectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC245054/pdf/aac00048-0223.pdf  a579-810 v35  aJI 19913 a<p>As determined by the proportional bactericide method, clarithromycin had strong bactericidal activity against Mycobacterium leprae. Clarithromycin was administered to mice by gavage as 20 daily doses at dosages of 12.5 to 50 mg/kg of body weight. At a dosage of 25 mg/kg, minocycline was more active than clarithromycin at a dosage of 50 mg/kg. Additive effects were displayed with the combination of clarithromycin (50 mg/kg) and minocycline (25 mg/kg), both of which were administered daily by gavage, and of clarithromycin and minocycline, both of which were administered daily by gavage at dosages of 25 mg/kg each, with rifampin at a single oral dose of 10 mg/kg.</p>  a0066-4804