01454nas a2200313   4500000000100000008004100001260001600042653001000058653001500068653001600083653002000099653002400119653001100143653001100154653002300165653001200188653000900200653001300209653001600222100001600238700001700254700001200271700001200283245010700295300001100402490000700413520070600420022001401126       2009                            d  c2009 Nov 2310aAdult10aBangladesh10aBCG Vaccine10aChemoprevention10aDouble-Blind Method10aFemale10aHumans10aLeprostatic Agents10aleprosy10aMale10aRifampin10aYoung Adult1 aSchuring RP1 aRichardus JH1 aPahan D1 aOskam L00aProtective effect of the combination BCG vaccination and rifampicin prophylaxis in leprosy prevention.  a7125-80 v273 a<p>BCG vaccination and rifampicin chemoprophylaxis are both strategies for leprosy prevention. While the combined effect is unknown, the combination may give the desired push to halt leprosy transmission. Secondary analysis was done on results from a single centre, double blind, cluster randomized, and placebo-controlled trial. Individually, BCG (given at infancy) and rifampicin showed to protect against leprosy (57% [95% CI: 24-75%] and 58% [95% CI: 30-74%], respectively). The combined strategies showed a protective effect of 80% (95% CI: 50-92%). This is the first time that the additive effect of BCG and rifampicin are shown; the combined strategies can possibly lower leprosy incidence.</p>  a1873-2518