01948nas a2200385   4500000000100000008004100001260001300042653001000055653001100065653001100076653001900087653003800106653001300144653001500157653004000172653001100212653001200223653000900235653001600244653001900260100002100279700001500300700001800315700001300333700001600346700001300362700001400375700001800389700002200407245009800429300001100527490000700538520100300545022001401548       2008                            d  c2008 Nov10aAdult10aBrazil10aFemale10aGene Frequency10aGenetic Predisposition to Disease10agenotype10aHaplotypes10aHistocompatibility Antigens Class I10aHumans10aleprosy10aMale10aMiddle Aged10aReceptors, KIR1 aFranceschi D S A1 aMazini P S1 aRudnick C C C1 aSell A M1 aTsuneto L T1 aMelo F C1 aBraga M A1 aPeixoto P R F1 aVisentainer J E L00aAssociation between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.  a478-820 v723 a<p>The aim of this study was to investigate the role of killer cell immunoglobulin-like receptor (KIR) genes in leprosy immunopathogenesis. Genotyping of KIR and human leukocyte antigen (HLA) genes was performed by polymerase chain reaction with sequence-specific oligonucleotide probes in 165 leprosy patients. Both activating KIR2DS2 and KIR2DS3 frequencies were higher in tuberculoid leprosy (TT) patients than in lepromatous leprosy (LL) patients, and the inhibitory KIR with its ligand, KIR2DL1-C2/C2, was elevated in TT patients in comparison to all other leprosy subgroups and controls. However, a negative association between KIR2DL3-C1 and KIR2DL3-C1/C1 and the TT group was identified. Borderline patients exhibited a higher frequency of KIR3DL2-A3/11 than the controls and LL patients, and a lower frequency of KIR2DL1-C2 than the controls and TT subgroup. Some KIR-HLA genotypes could be associated to the development of clinical forms of leprosy and should be investigated further.</p>  a1399-0039