01304nas a2200325   4500000000100000008004100001260001300042653001200055653001900067653001100086653004100097653001200138653002500150653002000175653003600195653002100231653002700252100001300279700001200292700001500304700001500319700001200334700001200346245013000358856007200488300001100560490000700571520038600578022001400964       2010                            d  c2010 Sep10aAnimals10aDNA, Bacterial10aFemale10aInfectious Disease Incubation Period10aleprosy10aMycobacterium leprae10aPan troglodytes10aPolymorphism, Single Nucleotide10aPrimate Diseases10aSequence Analysis, DNA1 aSuzuki K1 aUdono T1 aFujisawa M1 aTanigawa K1 aIdani G1 aIshii N00aInfection during infancy and long incubation period of leprosy suggested in a case of a chimpanzee used for medical research.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937736/pdf/0017-10.pdf  a3432-40 v483 a<p>The length of the incubation period of leprosy following Mycobacterium leprae infection has never been conclusively determined, owing to the lack of a method to demonstrate the presence of an asymptomatic infection. We report a rare case of leprosy in a chimpanzee in which a 30-year incubation period was strongly suggested by single nucleotide polymorphism (SNP) analysis.</p>  a1098-660X