02075nas a2200145   4500000000100000008004100001100001200042700002000054700001200074245009100086856005500177300001100232490000700243520167900250       2019                            d1 aIdris I1 aKuliya-Gwarzo A1 aAhmed S00aHigh hemolytic markers in G6PD-deficient compared to G6PD-normal male leprosy patients  uhttp://www.njbcs.net/text.asp?2019/16/2/109/270999  a109-130 v163 aIntroduction: Glucose-6-phosphate dehydrogenase (G6PD) deficiency (Gd−) is the most common enzymopathy, which is inherited as an X-linked recessive disorder. Individuals with Gd− are prone to hemolysis upon exposure to oxidant stress. Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae. Both leprosy and Gd− are common in Nigeria, and treatment of leprosy with dapsone can precipitate hemolysis in Gd−. Aims: The aims of this study were to determine the prevalence of Gd−, and compare the hematological and biochemical indices of Gd− with G6PD-replete (Gd+) male leprosy patients in Kano, Nigeria. Settings and Design: This was a cross-sectional study. A total of 198 male participants with leprosy were recruited at the Yadakunya leprosarium in Kano, Nigeria. Materials and Methods: Relevant data were obtained through questionnaires and case notes review. Venous blood was collected for analysis. Statistical Analysis: Unpaired t test and Chi square test were used for comparison of variables. Results: The prevalence of G6PD deficiency was 9% in male leprosy patients. Mean Hb of Gd−(10.56 ± 2.82 g/dl) was lower than Gd+(12.9 ± 2.31 g/dl), P value < 0.001. Platelet (293.52 × ±3.19 × 109/l vs. 176.31 ± 2.83 × 109/l; P value < 0.001), reticulocytes (4.49 ± 2.72% vs. 2.01 ± 1.07%, P value < 0.001), bilirubin [1.04 ± 0.22 mg/dl vs. 0.46 ± 0.27 mg/dl; P value < 0.001], and lactate dehydrogenase (LDH) [269.82 ± 58.54 mg/dl vs. 130.26 ± 51.83 mg/dl; P value <0.001] were higher in Gd− than Gd+. Conclusion: Lower Hb and higher hemolytic markers in Gd− indicate ongoing hemolysis, which can be precipitated by dapsone.