01256nas a2200217   4500000000100000008004100001260001200042653002300054653002200077653001200099653002100111100001400132700001300146700001500159700001300174700001500187700001300202245012800215520068100343022001401024       2019                            d  c12/201910aT regulatory cells10aimmunosuppression10aleprosy10aleprosy reaction1 aCardona C1 aVieira A1 aAvancini J1 aDuarte A1 aTrindade M1 aBenard G00aExpansion and suppressive capacity of regulatory T cells isolated from patients across the leprosy spectrum: a pilot study.3 a<p>Knowledge of the role of Tregs in the immunopathogenesis of the different clinical outcomes within the leprosy spectrum remains limited due to the lack of studies directly assessing their suppression capacity. We thus tested a protocol to expand Tregs from the peripheral blood of patients across the leprosy spectrum and analyzed their suppressive capacity in autologous TCD4+ responses. Results of these pilot assays show that Tregs can be expanded and exert suppressive capacity, but also that their rate of expansion and suppressive capacity are influenced by the patient's clinical classification, suggesting that they possibly retain some in vivo characteristics.</p>  a1769-714X