01670nas a2200253   4500000000100000008004100001260001200042653001300054653001800067653001200085653001700097653001400114100001300128700001400141700001500155700001500170700001400185700001600199700001400215245011300229300001100342520104900353022001401402       2020                            d  c01/202010aAntibody10aComplications10aleprosy10aMycobacteria10aTreatment1 aDuthie M1 aRoferos F1 aAbellana J1 aTaborada T1 aSanchez R1 aMaghanoy AA1 aBalagon M00aUtility and limitations of serodiagnostic tests in monitoring the response to treatment of leprosy patients.  a1149843 a<p>Simple measures that can facilitate early recognition of leprosy complications are still lacking. We therefore evaluated a lateral flow-based rapid diagnostic test and fast enzyme-linked immunosorbent assay measuring anti-LID-NDO antibody responses among leprosy cases in Cebu, Philippines. Responses were measured at diagnosis, then during and after the provision of standard multidrug therapy. Our data indicate that both platforms are highly sensitive tools for the primary diagnosis of, in particular, multibacillary leprosy. A gradual, quantifiable decline in both magnitude of response and percent positive responders was observed during and after treatment. As a group, patients that developed erythema nodosum leprosum (ENL) had a significantly higher response at diagnosis than patients that either developed reversal reactions or did not develop reactions. Although higher initial anti-NDO-LID responses were a risk factor for ENL, neither platform, however, could reliably predict the time of emergence of reactional episodes.</p>  a1879-0070