01476nas a2200121   4500000000100000008004100001100001200042245011200054856004100166300001200207490000600219520112900225       2019                            d1 aIlyas F00aDiscrepancy between clinical manifestations and histopathological features in borderline borderline leprosy  uhttp://mdpub.net/index.php?mno=34368  a286-2890 v33 aLeprosy is a chronic and progressive granulomatous disease that primarily affects the skin and peripheral nervous system caused by Mycobacterium leprae. If left unrecognized, infection can cause permanent nerve damage and disability. The mid-borderline type is the most unstable type, where clinical presentation depends on the patient's immune response and may result in a broad spectrum of symptoms. ROM (rifampicin, ofloxacin, minocycline) is second-line therapy for leprosy recommended by WHO for patients who have contraindications or reject MDT administration.
A case of a 49-year-old male patient was reported with ulcer on the right hand, peeled skin on both hands, legs, accompanied with erythematous nodules and plaque, and hyperpigmented macules almost all over body. Skin all over body were painful and followed with fever. Clinical manifestation is mimicking borderline lepromatous and severe leprosy reaction, but histopathology result support Borderline borderline leprosy. The ptient was treated with Rifampisin, Ofloxacin, Minoksiklin (ROM) and Prednison, which resulted in significant clinical improvement