01324nas a2200157   4500000000100000008004100001260001200042100001200054700001300066700001200079700001400091700001200105245009500117520094000212022001401152       2020                            d  c02/20201 aKamat D1 aNarang T1 aAhuja M1 aLavania M1 aDogra S00aCase Report: Multidrug-Resistant Mycobacterium leprae in a Case of Smear-Negative Relapse.3 a<p>The ongoing transmission of leprosy in India is worrisome, and emerging drug resistance may be one of the factors responsible for the continued transmission of leprosy in India. Emerging cases of multidrug-resistant  pose a great threat to eradication of leprosy and must be addressed with utmost priority. We report a case of multidrug-resistant  in a case of relapse where slit skin smear (SSS) was negative and histopathology was inconclusive. Drug resistance studies in leprosy are undertaken only in smear-positive relapse cases, and detection of this type of multidrug resistance in a case with negative SSS and innocuous histopathology is rather unusual and highlights the importance of undertaking drug resistance tests even in smear-negative cases of leprosy relapse. Resistance to ofloxacin (OFL) is also a cause for concern as OFL is one of the reserve drugs recommended for treatment of rifampicin-resistant strains.</p>  a1476-1645