01397nas a2200385 4500000000100000008004100001260001200042653000800054653002500062653001600087653001700103653002900120653001300149653001100162653002000173653003300193653001100226653001200237653001700249653000900266653000800275653003600283653004000319100001100359700001600370700001600386700001100402700001500413245009100428856005900519300001200578490000700590520040000597022001400997 2020 d c03/202010a3K110aMycobacterium leprae10aPhilippines10aSaudi Arabia10aantimicrobial resistance10abacteria10abiopsy10adrug resistance10aimported infectious diseases10aindels10aleprosy10ametagenomics10arpoB10arrs10asingle-nucleotide polymorphisms10atuberculosis and other mycobacteria1 aGuan Q1 aAlmutairi T1 aAlhalouli T1 aPain A1 aAlasmari F00aMetagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017. uhttps://wwwnc.cdc.gov/eid/article/26/3/19-0661_article a615-6170 v263 a
Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically observed. Metagenomics sequencing can be used to identify multidrug-resistant M. leprae.
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