01909nas a2200289   4500000000100000008004100001260001200042653001200054653002500066653003300091653001600124653002200140653001600162100002600178700001300204700002600217700001400243700001300257700001200270700001800282700001400300700001500314245012600329856008300455520106700538022001401605       2020                            d  c04/202010aleprosy10aMycobacterium leprae10aRecombinant protein antigens10aSensitivity10aSerological tests10aSpecificity1 aGrossi de Oliveira AL1 aFraga VG1 aSernizon-Guimarães N1 aCardoso M1 aViana AG1 aBueno L1 aBartholomeu D1 aMenezes C1 aFujiwara R00aDiagnostic accuracy of tests using recombinant protein antigens of Mycobacterium leprae for leprosy: A systematic review.  uhttps://www.sciencedirect.com/science/article/pii/S187603412030397X?via%3Dihub3 a<p>The aim of this systematic review was to investigate the studies that evaluated the sensitivity and specificity of serologic tests using recombinant protein antigens from Mycobacterium leprae for leprosy diagnosis. We included 13 studies that were available in PubMed, Brazilian Virtual Library of Health, Web of Science, ScienceDirect and Scopus. From these studies, we found that the recombinant serine-rich 45-kDa protein of M. leprae (ML0411) demonstrated high performance for multibacillary (MB) also to paucibacillary (PB) patients, although this study was tested only for Indian population. Despite that, studies using the ND-O-LID antigen have been able to more accurately identify new cases of leprosy among people living in endemic or non-endemic areas and household contacts in Brazil, Colombia, and the Philippines, especially when combined with other biomarkers. Finally, low sensitivity values for PB patients' antibodies response remain challenging for tests intended to diagnose clinical forms that comprise this classification in leprosy.</p>  a1876-035X