01235nas a2200253   4500000000100000008004100001260001200042653002500054653001200079653000900091653001800100100001500118700001500133700001500148700001700163700001700180700001600197700001500213700001400228700001400242245008800256520062300344022001400967       2020                            d  c10/202010aMycobacterium leprae10aleprosy10amice10areal time PCR1 aKaramova A1 aSemenova V1 aVerbenko D1 aObraztsova O1 aVanchugova K1 aNikonorov A1 aDeryabin D1 aSolomka V1 aKubanov A00aExperimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF Mice.3 a<p>Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF mice.</p>  a1573-8221