01554nas a2200229   4500000000100000008004100001260001200042653001200054653002300066653003300089653002800122100001400150700001600164700001400180700001400194245008100208856007400289300001200363490000600375520092900381022001401310       2020                            d  c01/202010aleprosy10apunched-out ulcers10areactive perforating leprosy10aType 2 leprosy reaction1 aGunawan H1 aNursjamsi N1 aAchdiat P1 aSuwarsa O00aReactive perforating leprosy: A rare case report of type 2 leprosy reaction.  uhttps://www.ijmyco.org/temp/IntJMycobacteriol94451-3612323_100203.pdf  a451-4530 v93 a<p>Reactive perforating leprosy (RPL) is a rare clinical manifestation of type 2 leprosy reaction. A case of lepromatous leprosy (LL) with type 2 leprosy reaction presented as RPL in one patient was reported. A physical examination showed multiple punched-out ulcers with regular border, without undermined edge, and dermal base. The ulcers mostly covered with hemorrhagic crust, contained pus, and necrotic tissue. A histopathological examination revealed invagination of the epidermis, intracorneal abscess, and infiltration of foamy macrophages with lymphocytes in dermis that supported the diagnosis of LL with RPL. The patient was given multidrug therapy-multibacillary and 40 mg prednisone daily which tapered off and wound dressing. Clinical improvement was observed within 2 weeks of treatment, as some ulcers healed. Type 2 leprosy reaction can provide a variety of clinical manifestations, one of which is RPL.</p>  a2212-554X