01648nas a2200253 4500000000100000008004100001260001200042653001200054653002000066653001600086653003800102653001000140653006000150100001300210700001500223700001200238700001400250700001500264700001100279245007800290300001900368520099300387022001401380 2021 d c03/202110aleprosy10anon-neuropathic10anon-trophic10apseudoepitheliomatous hyperplasia10aulcer10aulcerated Sweet syndrome-like erythema nodosum leprosum1 aShukla P1 aMalhotra K1 aVerma P1 aSuvirya S1 aSaraswat A1 aJain A00aUnusual non-trophic ulcerations in leprosy: A case series of 17 patients. a494755219984993 a

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley-Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. We found 17/386 leprosy patients with non-neuropathic ulcers. We describe three causes - spontaneous cutaneous ulceration in lepromatous leprosy (one nodular and one diffuse), lepra reactions (five patients with type 1; nine with type 2, further categorised into ulcerated Sweet syndrome-like who also had pseudoepitheliomatous hyperplasia, pustulo-necrotic and necrotic erythema nodosum leprosum) and Lucio phenomenon (one patient). Our series draws attention towards the different faces of non-neuropathic ulcers in leprosy, including some atypical and novel presentations.

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