02688nas a2200301   4500000000100000008004100001260001200042653002500054653003100079653001800110653001200128653003500140653001700175100000900192700001100201700001100212700001100223700001000234700001100244700001100255700001200266245014800278856008100426300001100507490000700518520184700525022001402372       2021                            d  c01/202110aMycobacterium leprae10aMycobacterium tuberculosis10aPTPN22-C1858T10aleprosy10asingle-nucleotide polymorphism10atuberculosis1 aLi S1 aWang X1 aZhao Y1 aYang J1 aCui T1 aZhao Z1 aChen Y1 aZheng Z00aAssociation of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7950544/pdf/fimmu-12-592841.pdf  a5928410 v123 a<p>It was previously published that single-nucleotide polymorphism rs2476601 ( [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to  and  infection. However, the results were inconclusive despite a high degree of similarity between both parameters. Herein, we carried out this meta-analysis to systematically summarize and articulate the correlation between -C1858T polymorphism and mycobacterial infection. The susceptibility of -C1858T carriers with autoimmune conditions receiving immunosuppressive therapy to  and  infection was determined. A systematic retrieval of studies on relevance of -C1858T polymorphism to susceptibility of  or  infection was performed in Chinese National Knowledge Infrastructure, PubMed and Embase databases. We regarded Odds ratios (ORs) and 95% confidence intervals (CIs) as the determined effect size. Finally, four and two case-control studies on tuberculosis and leprosy, respectively, were included. In all genetic models, without indicated association between -C1858T polymorphism and tuberculosis's susceptibility. [C versus T: OR = 0.22 (95% CI: 0.09-0.50, P = 0.887); CT versus CC: OR = 0.21 (95% CI: 0.09-0.49, P = 0.889); TT+CT versus CC: OR = 0.21 (95% CI: 0.09-0.49, P = 0.889)]. A significantly increased risk of leprosy was perceived in patients with the -C1858T polymorphism [C versus T: OR = 2.82 (95% CI: 1.02-7.81, P = 0.108)]. While the -C1858T polymorphism is irrelevant to higher susceptibility to the infection of  in Caucasians and Asians, it is relevant to increased susceptibility to the infection of . However, the results of  are supposed to interpreted with prudence owing to the limited quantity of studies and heterogeneity. Further well-designed studies with sufficient populations are required to verify our conclusions.</p>  a1664-3224