02391nas a2200241 4500000000100000008004100001260001200042653002000054653003300074653001200107100001400119700001400133700001400147700001700161700001500178700001500193245012200208856007500330300001200405490000700417520171100424022001402135 2020 d c10/202010aBacterial index10aInsulin like growth factor 110aleprosy1 aSantosa C1 aRusyati L1 aAdiguna M1 aPraharsini I1 aWiraguna A1 aWardhana M00aCorrelation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali. uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992574/pdf/ad-32-370.pdf a370-3740 v323 a

Background: Leprosy is an infection by , which influenced by cellular immunity. Leprosy tends to occur in low socio-economic and nutrition groups. Researchers try to prove the role of nutrition in the pathogenesis of leprosy. Insulin-like growth factor-1 (IGF-1) as a marker of nutritional status shown to play a role in cellular immunity.

Objective: To evaluate the correlation between IGF-1 with bacterial index (BI) on leprosy patients in Bali.

Methods: Cross-sectional study in Sanglah Public General Hospital, Denpasar of patients with paucibacillary (PB) and multibacillary (MB) leprosy were assessed for BI using slit-skin smear. All patients were tested for plasma IGF-1 using chemiluminescent immunometric assay Immulite. All data were analyzed using IBM SPSS ver. 24.0. The study has been approved by local Institutional Review Board with ethical clearance number 2017.02.1.0356.

Results: Our study involved 44 MB and 2 PB leprosy. The common age group affected was between 31~40 years old (23.9%), male (60.9%), and normal body mass index (BMI) (65.2%). Mean plasma IGF-1 level in PB leprosy was higher (91.07±0.74 ng/ml) than MB (82.74±6.44 ng/ml). The mean IGF-1 level decreases as BI increases in both groups (CI 95%=81.16~85.04; <0.001). Pearson correlation test shows strong negative correlation (Pearson r=-0.976; <0.001) with determinant coefficient (R) showing 95.2% (<0.001).

Conclusion: In Balinese leprosy patients, severity of disease status measured by BI were found to be strongly correlated with the plasma IGF-1 level which may help preventing transmission in household contacts by improving nutritional status.

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