01700nas a2200241   4500000000100000008004100001260001200042653002500054653000900079653001000088653001200098653001900110100001400129700001600143700001400159700001800173245009600191856007800287300001200365490000700377520106000384022001401444       2021                            d  c01/202110aMycobacterium leprae10abone10ajoint10aleprosy10asynovial fluid1 aGunawan H1 aWulansari Y1 aAchdiat P1 aHindritiani R00aLeprosy-Related Chronic Arthritis with an Abundance of  in the Synovial Fluid: A Rare Case.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184239/pdf/imcrj-14-371.pdf  a371-3760 v143 a<p>Bone and joint involvements are the most common manifestation in leprosy, after cutaneous and neurological manifestations, yet are underdiagnosed and rarely reported. We report a case of lepromatous leprosy in a 41-year-old male with bone and joint changes. Physical examination revealed a leonine face, madarosis, hypesthetic hypopigmented macules on the back, and swelling of fingers and toes. Acid-fast bacilli from slit-skin smear and synovial fluid in an interphalangeal joint of the hand were found. Radiographic features showed osteolysis and destruction of some phalanges of the hands, bone erosion and destruction of some phalanges of the feet, as well as destruction and subluxation of some hand joints. The patient was given multidrug therapy for multibacillary leprosy, resulting in the reduction of swelling in fingers and toes. In conclusion, the examination of bone and joint changes in leprosy patients is important for early detection and management of musculoskeletal complications, to prevent future deformities and disabilities.</p>  a1179-142X