01894nas a2200229   4500000000100000008004100001260001200042653001200054653001300066653002300079100002500102700002100127700001300148700001700161700001600178700001300194700001400207245012300221856007900344520122700423022001401650       2021                            d  c06/202110aleprosy10agenotype10avitamin D receptor1 aLetícia Pinto Paz J1 aSilvestre MDPSCA1 aMoura LS1 aFurlaneto IP1 aRodrigues Y1 aLima KVB1 aLima LNGC00aAssociation of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon.  uhttps://portlandpress.com/bioscirep/article-lookup/doi/10.1042/BSR202041023 a<p>The transmission and evolution of leprosy depends on several aspects, including immunological and genetic factors of the host, as well as genetic factors of Mycobacterium leprae. This study evaluated the association of single nucleotide polymorphisms (SNPs) on the FokI (rs2228570), TaqI (rs731236), ApaI (rs7975232) regions of the vitamin D receptor (VDR) gene with leprosy. A total of 405 individuals were evaluated, composed by groups of 100 multibacillary and 57 paucibacillary patients, and 248 healthy contacts. Blood samples were collected from patients and contacts. The genotyping was performed by sequencing of the interest regions. The alleles of the studied SNPs, and of SNP FokI genotypes, were not associated with leprosy. For the SNP on TaqI region, the relationship between the tt genotype, and for the SNP ApaI, the AA genotype, revealed an association with susceptibility to MB form, while Aa genotype with protection. The extended genotypes AaTT and AaTt of ApaI and TaqI were associated with protection to against MB form. Futher studies analyzing the expression of the VDR gene and the correlation with its SNPs might help to clarify the role of polymorphisms on the immune response in leprosy.</p>  a1573-4935