02037nas a2200253   4500000000100000008004100001260001200042653001300054653002200067653002100089653001600110653001200126653003200138100001200170700001400182700001300196700001400209245012000223856005800343300001200401490000700413520134900420022001401769       2021                            d  c01/202110aCytokine10agene polymorphism10ainterferon gamma10ainterleukin10aleprosy10atumor necrosis factor alpha1 aKolla V1 aSultana S1 aDavala S1 aValluri V00aA Study on the Impact of Genetic Polymorphisms of Cytokines TNFα, IFNγ and IL10 in South Indian Leprosy Patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208288/  a138-1440 v663 a<p><b>Background: </b>Leprosy (Hansen's disease) is a chronic, debilitating disease predominantly of the peripheral nervous system characterized by the impairment of peripheral nerves and subsequent sensory loss caused by . The pro- and antiinflammatory cytokine genes play a major role in nerve damage in leprosy.</p><p><b>Aims and Objectives: </b>The objective of the present study is to ascertain the association of cytokine gene polymorphisms TNFα - 308G/A (rs 1800629), IFNγ +874A/T (rs 2430561), and IL10 - 1082G/A rs 1800896 in causation with leprosy.</p><p><b>Materials and Methods: </b>The present study comprised 365 leprosy patients and 185 control subjects. The polymorphisms in TNFα-308, IFNγ+874, and IL10-1082 genes were typed using the amplification refractory mutation system polymerase chain reaction method (ARMS PCR).</p><p><b>Results: </b>The present study found significant association between IL10-1082 GA heterozygote ( < 0.02) and IFNγ+874 AA ( < 0.001) genotype and leprosy. TNFα-308GA could not establish any association with the disease.</p><p><b>Conclusion: </b>The identification of genetic variations in pro- and antiinflammatory cytokines that are susceptible to leprosy would assist in better understanding of the pathogenesis of leprosy and perhaps lead to new approaches for diagnosis and treatment.</p>  a1998-3611