01543nas a2200301   4500000000100000008004100001260001200042653003000054653002100084653002500105653001200130100002100142700001300163700001300176700001500189700001100204700001500215700001300230700001700243700001800260700001200278700001300290245012300303856008100426300000900507520071100516022001401227       2021                            d  c10/202110aErythema nodosum leprosum10aLucio phenomenon10aMycobacterium leprae10aleprosy1 aCipriani Frade M1 aColtro P1 aFilho FB1 aHorácio G1 aNeto A1 ada Silva V1 aWestin A1 aGuimarães F1 aInnocentini L1 aMotta A1 aJunior J00aLucio's phenomenon: A systematic literature review of definition, clinical features, histopathogenesis and management.  uhttps://ijdvl.com/view-pdf/?article=2fb9b24a1297177fe1e8e01ff86a46fbFVLo8/4=  a1-143 a<p>Leprosy is a chronic disease with clinical presentations according to the immunologic spectrum. Lepromatous form is the most advanced, with the highest transmissibility and risk of causing disabilities. Lucio's phenomenon is a rare manifestation among lepromatous patients with a rapid and severe evolution and high mortality. It is difficult to differentiate from ulcerative/necrotic erythema nodosum leprosum and has no consensus on how it should be treated. This article is a qualitative review of the literature after the introduction of multidrug therapy, aiming to bring consensus related to the clinical, laboratory and histopathological diagnostic criteria of the disease and its management.</p>  a0973-3922