01443nas a2200181   4500000000100000008004100001260001200042653002100054653001200075653002900087653001300116100001200129700001300141245012200154856008300276520088800359022001401247       2021                            d  c11/202110aErythema nodosum10aleprosy10aMycobacterium infections10aVaccines1 aGupta S1 aKumari S00aChronic recalcitrant erythema nodosum leprosum: therapeutic dilemma and role of mycobacterium indicus pranii vaccine.  uhttps://www.sciencedirect.com/science/article/pii/S0365059621002579?via%3Dihub3 a<p>Erythema nodosum leprosum is a severe immune reaction that complicates the usual course of multibacillary leprosy. There is increased activation of T-cells in erythema nodosum leprosum. Treatment modalities available to date for the management are systemic steroids, thalidomide, methotrexate, cyclophosphamide, azathioprine, minocycline, and apremilast but none of them is promising and safe. Mycobacterium indicus pranii is an atypical mycobacterium possessing strong immunomodulatory properties. The vaccine for this mycobacterium has been shown to have both immunotherapeutic and immunoprophylactic effects in multibacillary leprosy patients. We report a case of chronic recalcitrant erythema nodosum Leprosum which responded to Mycobacterium indicus pranii vaccine without any adverse effects, thereby suggesting its role as a novel therapeutic option in this reaction.</p>
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