01131nas a2200205   4500000000100000008004100001260001000042653002100052100001400073700001900087700001400106700001300120700001300133245011400146856009800260300001200358490000700370520053400377022001400911       2021                            d  bLepra10aGeneral Medicine1 aAbideen F1 aBalakrishnan S1 aSindhu CB1 aGeorge S1 aSanker A00aA unique case of borderline lepromatous leprosy presenting with both hypopigmented and hyperpigmented macules  uhttps://leprosyreview.org/admin/public/api/lepra/website/getDownload/61b84885afaac1246d764255  a412-4200 v923 a<p>Primary hyperpigmentation is rare in leprosy. We report a patient with borderline lepromatous (BL) leprosy who presented with both hypopigmented and hyperpigmented macules. Histopathology with Masson Fontana staining and immunohistochemistry with HMB 45 revealed decreased melanin granules in keratinocytes of basal and superficial layers in hypopigmented macules when compared to hyperpigmented macules. It appears that hypopigmentation in leprosy lesions may be due to defective transfer of melanin into keratinocytes.</p>
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