01659nas a2200337   4500000000100000008004100001260001300042653002900055653001600084653001600100653004100116653001100157653002500168653001200193653001600205653001600221653002500237653002200262100001500284700002100299700001400320700001300334700001300347245012500360856004100485300001000526490000700536050001500543520074900558022001401307       1990                            d  c1990 Sep10aAntigen-Presenting Cells10aEndothelium10aFibroblasts10aHistocompatibility Antigens Class II10aHumans10aImmunohistochemistry10aleprosy10aLymphocytes10aMacrophages10aMicroscopy, Electron10aPeripheral nerves1 aCowley S A1 aGschmeissner S E1 aNegesse Y1 aCurtis J1 aTurk J L00aMajor histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study.  uhttp://ila.ilsl.br/pdfs/v58n3a15.pdf  a560-50 v58  aCOWLEY19903 a<p>A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons.</p>  a0148-916X