01703nas a2200253   4500000000100000008004100001260001200042653003000054653001500084653002500099653001200124653001400136100001200150700000900162700001200171700000900183700001200192245011300204856008900317300001100406490000700417520101100424022001401435       2022                            d  c01/202210aAntiphospholipid Syndrome10aAutoimmune10aDeep vein thrombosis10aleprosy10aPediatric1 aJones D1 aCA J1 aJoshi A1 aAS S1 aKumar H00aDeep Vein Thrombosis in Lepromatous Leprosy: A Case Report of Secondary Pediatric Antiphospholipid Syndrome.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853942/pdf/cureus-0014-00000021361.pdf  ae213610 v143 a<p>Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by thromboembolic events, fetal loss during pregnancy, and evidence of antiphospholipid (aPL) antibodies such as beta-2-glycoprotein I (B2-GPI) and anticardiolipin (aCL). The diagnosis and treatment of this condition in the pediatric population have limited literature evidence due to the rarity of the condition in this age group. Guidelines have been adopted from the adult counterpart of the affected population, thereby giving rise to diagnostic and therapeutic challenges. In this report, we describe a rare case of a 15-year-old male who presented with lepromatous leprosy and developed deep vein thrombosis in his right leg. The laboratory evidence of positive aPL antibodies guided our diagnosis of APS and treatment with oral anticoagulants. This report highlights the importance of screening and timely diagnosis of APS in the pediatric population presenting with venous thrombosis in the backdrop of infection.</p>
  a2168-8184