01085nas a2200229   4500000000100000008004100001260001200042653001200054653001900066653001600085653001200101653001600113653001400129653001500143100001500158700001300173700001300186700001300199245010400212520052500316022001400841       2022                            d  c04/202210aleprosy10aClarithromycin10aClofazimine10aDapsone10aMinocycline10aOfloxacin10aRifampicin1 aPinheiro L1 aBorges J1 aCampos V1 aDantas L00aAn Overview of Treatment Guidelines and Methods of Synthesis of Drugs Used in Leprosy Chemotherapy.3 a<p>Leprosy is a neglected tropical disease (NTDs) caused by Mycobacterium leprae (M. leprae). The treatment is considered effective, however, the high dose multidrug therapy (MDT) for a long period and its adverse effects result in the abandonment of the treatment by patients. Indeed, antimicrobial resistance is still an obstacle that must be overcome in the treatment of leprosy. In the present article, we reviewed the WHO guidelines for the chemotherapy of leprosy and the methods of synthesis of these drugs.</p>
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