02162nas a2200337   4500000000100000008004100001260001200042653000900054653000900063653002900072653001200101653003000113100001200143700001500155700001400170700001100184700001800195700001100213700001500224700001500239700001500254700001100269700002300280700001800303245009100321856008100412300001100493490000700504520129900511022001401810       2022                            d  c01/202210aTLR110aTLR210ainnate immunity response10aleprosy10atoll-like receptors (TLR)1 aMasin P1 aVisentin H1 aElpidio L1 aSell A1 aVisentainer L1 aNeto Q1 aZacarias J1 aCouceiro P1 aShinzato A1 aRosa M1 aRodrigues-Santos P1 aVisentainer J00aGenetic polymorphisms of toll-like receptors in leprosy patients from southern Brazil.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596761/pdf/fgene-13-952219.pdf  a9522190 v133 a<p>Leprosy is a chronic disease and also a global health issue, with a high number of new cases per year. Toll-like receptors can respond to mycobacterial molecules in the early stage of infection. As important components of the innate immune response, alterations in genes coding for these receptors may contribute to susceptibility/protection against diseases. In this context, we used a case-control study model (183 leprosy cases vs. 185 controls) to investigate whether leprosy patients and the control group, in southern Brazil, have different frequencies in ( G&gt;T; rs5743618), ( T&gt;C, rs1816702 and rs4696483), and ( A&gt;G, rs1927911) polymorphisms. Analysis of the 1805G&gt;T polymorphism presented the genotype more frequently in the control group. T&gt;C rs1816702 and T&gt;C rs4696483, the T/T and C/T genotype, respectively, were more frequent in the control group than in leprosy patients, suggesting protection from leprosy when the T allele is present (rs4696483). Haplotype analyses between (rs5743618) and (rs1816702 and rs4696483) polymorphisms suggest risk for the presence of the TCC haplotype and protection in the presence of the TCT haplotype. This study suggests that polymorphisms in and are factors that may contribute to development/resistance of leprosy.</p>
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