02433nas a2200277   4500000000100000008004100001260001200042653005300054653003700107653001200144653002100156100001300177700001800190700001600208700001700224700001300241700001300254700001500267700001600282700001600298245017800314856009000492300000800582520155100590022001402141       2022                            d  c12/202210aAdipose mesenchymal stem cell-conditioned medium10achronic plantar ulcer of leprosy10aleprosy10aTropical disease1 aAlinda M1 aChristopher P1 aListiawan M1 aEndaryanto A1 aSuroto H1 aRantam F1 aHendradi E1 aNotobroto H1 aPrakoeswa C00aThe efficacy of topical adipose mesenchymal stem cell-conditioned medium versus framycetin gauze dressing in chronic plantar ulcer of leprosy: A randomized controlled trial.  uhttps://ijdvl.com/view-pdf/?&article=db3b4ef488d8eec194126f020cef8aed4Q2njtrwcwOWgg==  a1-63 a<p>Background Wound healing shows a unique interaction of several cells, growth factors and cytokines. The healing of chronic plantar ulcer of leprosy is influenced by various factors, one of which is the concentration of growth factors and cytokines related to the pathogenesis of impaired wound healing. Growth factors and cytokines can be found in the secretome of adipose mesenchymal stem cells. Aim To compare the effectiveness of topical adipose mesenchymal stem cell-conditioned medium and framycetin gauze dressing only on the healing of chronic plantar ulcer of leprosy. Methods In this randomised controlled trial, 32 patients with chronic plantar ulcer of leprosy were recruited. After detailed clinical and initial debridement, patients were randomised to two groups to receive either topical adipose mesenchymal stem cell-conditioned medium (n = 16) or framycetin gauze dressing only (n = 16) applied every three days for up to eight weeks, following which the ulcer size, adverse reactions and complications if any were monitored weekly. Results Healing percentage increased each week in all groups. Statistical differences between groups (P &lt; 0.05) were observed from week 2 onwards for ulcer mean size reduction and from week 3 onwards for ulcer mean depth reduction. There were no adverse reactions or complications. Limitations Off-loading on subjects were not performed. Conclusion Adipose mesenchymal stem cell-conditioned medium is a potential therapeutic agent in the management of chronic plantar ulcer of leprosy.</p>
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