01464nas a2200205   4500000000100000008004100001260001200042653002400054653002600078653001200104653001500116100001900131700001300150245005600163856007900219300001000298490000700308520092900315022001401244       2023                            d  c01/202310aAcute renal failure10aadverse drug reaction10aleprosy10aRifampicin1 aJeyasekharan R1 aGeorge N00aRifampicin Allergy Leading to Acute Renal Shutdown.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230526/pdf/IJABMR-13-47.pdf  a47-490 v133 a<p>Rifampicin is a widely used drug to treat tuberculosis and leprosy. Its toxicity is predominantly hepatic and immunoallergic in character. While hepatic toxicity is dose-related, the immunoallergic effects are unpredictable and usually associated with intermittent therapy. These immunoallergic effects may be minor (a cutaneous, gastrointestinal, or influenza-like syndrome) or major (hemolytic anemia, shock, or acute renal failure). Herein, we report a case of rifampicin allergy in a patient who was on intermittent once monthly rifampicin therapy for neuritic leprosy and was on his 4 month of treatment. Rifampicin exposure led to sudden shock and acute renal failure, which eventually required hemodialysis support. The patient made a complete recovery over the subsequent days and his renal function returned to normal over the next 3 weeks. He continues his multidrug therapy of leprosy without rifampicin.</p>
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