02239nas a2200361   4500000000100000008004100001260001200042653002100054653001200075653001800087653001100105100001400116700002000130700001400150700001800164700001800182700001600200700001500216700001700231700001300248700001200261700001600273700001400289700001700303700001400320700001500334245009900349856009000448300000800538490000700546520131000553022001401863       2023                            d  c07/202310aHumoral response10aleprosy10aPeriodontitis10aSaliva1 aFalcão M1 aPassos-Soares J1 aMachado P1 aGomes-Filho I1 ade Carvalho L1 ade Campos E1 aCalheira M1 ade Miranda P1 aSantos R1 aFilho J1 ade Farias A1 aPeixoto T1 aNascimento R1 aSeymour G1 aTrindade S00aThe leprosy reaction is associated with salivary anti-Porphyromonas gingivalis IgA antibodies.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328877/pdf/13568_2023_Article_1576.pdf  a1-80 v133 a<p>The aim of the study was to evaluate the association between salivary anti-Porphyromonas gingivalis IgA antibodies and the leprosy reaction. The levels of salivary anti - P. gingivalis IgA antibodies, together with salivary flow and pH were measured in individuals diagnosed with leprosy and associated with the development of the leprosy reaction. Saliva was collected from 202 individuals diagnosed with leprosy at a reference leprosy treatment center, 106 cases with the leprosy reaction and 96 controls without the leprosy reaction. Anti - P. gingivalis IgA was evaluated by indirect immunoenzyme assay. Non-conditional logistic regression analysis was employed to estimate the association between antibody levels and the leprosy reaction. There was a positive statistically significant association between the levels of anti - P. gingivalis IgA and the presence of the leprosy reaction, controlling for confounders: age, sex, level of education and alcoholic beverage consumption: OR: 2.55; IC 95%: 1.34-4.87. Individuals with leprosy who had high levels of salivary anti - P. gingivalis IgA had approximately twice as many chances of developing the leprosy reaction. The findings suggest a possible relationship between salivary anti - P. gingivalis IgA antibodies and the leprosy reaction.</p>
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